The antiproliferative effect of carotene juice on lung cancer cells in humans

Abstract

Nutrients that exhibit antioxidant properties and are found in plants may be protective against various types of cancers. carotenes present in carrots, which consist of a conjugted system, it is one of the molecules causing these effects. The amis of this work are identify the characteristics of carrote extract and evaluate its anti-cancer cell proliferation activity in vitro assay. carrote extract was obtained by blended of carrote, the carrote extract identified by UV–VIS Spectroscopy , and FTIR technique. Antiproliferative activity was estimated toward lung cancer cell line (HBE140-Human Bronchial Epithelial Cell Lines) by MTT assay. caroten juice have been showed Antiproliferactive effects in lung cancer cell line (HBE140-Human Bronchial Epithelial Cell Lines) in a dose dependent minner (0.2-0.8 µM) with IC50=2.19 µM. Therefore it can be concluded  that the carrote extract is a good natural resource as anti-cancer toward HBE140-Human Bronchial Epithelial Cell Lines.