Ecophysiological study of silver nanoparticles effect on the liver and regulatory cytokine in rabbit

Abstract

Silver naoparticles are widely used in treatments and as products using by human ,There is likelihood of release into the enivrements .That affect on health and environnemental concerns so their effect on liver must be studied.In this study silver nanoparticles were extracted from Morganella morganii and the rabbits were immunized with the extract to study the immunization capacity of Silver naoparticles. The liver function were studied by determine GPT and GOT and the serum level were increased (6.66,5.33) for test when compared with control(4.666, 4.667) respectively. The regulatory interleukines (IL-10 and IL-12)were determined By enzyme linked immunosorbent assay. The concentrations IL-10 were increased in test group(13.27) than in cotrol (10.25)while IL-12 concentrations were decreased in test group than control (14.20).The conclusion that Silver nanoparticles effect on function of rabbit liver and increase TH2 by increasing IL-10 and decrease IL-12 .